Chemical Hazard Data Availability Study

High Production Volume (HPV) Chemicals and SIDS Testing

Of the 3,000 chemicals that the US imports or produces at more than 1 million lbs/yr, a new EPA analysis finds that 43% of these high production volume chemicals have no testing data on basic toxicity and only seven percent have a full set of basic test data. This lack of test data compromises the public's right to know about the chemicals that are found in their environment, their homes, their workplace, and the products that they buy. Industry must do more to ensure that basic information is available on every high-production chemical they manufacture.

Background:

There are six basic tests which have been internationally agreed to for screening high production volume (HPV) chemicals for toxicity. The tests agreed to under the Organization for Economic Cooperation and Development's Screening Information Data Set (OECD/SIDS) program are: acute toxicity; chronic toxicity; developmental/reproductive toxicity; mutagenicity; ecotoxicity and environmental fate.

EPA found that approximately 55% of TRI chemicals have had full SIDS testing, while only 7% of other chemicals have full test data. EPA also looked at a set of 491 chemicals used by children and families in consumer products. Only 25% of these chemicals have full screening data. EPA cannot begin to judge the hazards and risks of such consumer chemicals without basic information, and in fact substantially more detailed and exhaustive testing is needed to assess these high exposure chemicals.

It is clear that companies need to do more to address this problem: of the 830 companies making HPV chemicals in the US, 148 companies have NO SIDS data available on their chemicals; an additional 459 companies sell products for which, on average, half or less of SIDS tests are available. Only 21 companies (or 3% of the 830 companies) have all SIDS tests available for their chemicals. The basic set of test data costs about $200,000 per chemical. ( http://www.epa.gov/opptintr/chemtest/hazchem.htm )

 

The European Commissions list of fragrance chemicals was cross referenced with the high production volume chemicals lists from the FDA. The following table lists the fragrance chemicals that are produced or imported in the US at a volume of 1 million pounds a year. The SIDS column indicates how many of the six basic testing data are available for the chemical. The status of those with * are not available.

Chemical CAS# SIDS
1,3,4,6,7,8 - hexahydro - 4,6,6,7,8,8 - hexamethylindeno(5,6 - c)pyran 1222055 0
3 - methyl - 4 - (2,6,6 - trimethyl - 2 - cyclohexen - 1 - yl) - 3 - buten - 2 - one 127515 0
butyl oleate 142778 0
methylheptenone 409029 0
(1a,2a,5a) - 2,2,6 - trimethylbicyclo(3.1.1)heptan - 2 - ol 4948281 0
Terpenes and Terpenoids, limonene fraction A complex combination of terpenes derived from oil of turpentine or citrus oils by fractionationor isomerization of other terpene fractions. Contains at least 80% limonene, the remainder being other terpene hydrocarbons. May contain trace amounts of alcohols, ethers, aldehydes, or ketones. 65996987 0
Rosin, hydrogenated 65997060 0
2,6 - dimethylocta - 2,4,6 - triene 673847 0
Resin acids and Rosin acids, Me esters 68186141 0
1,6 - Octadiene, 7 - methyl - 3 - methylene - , acetylated 68412044 0
Octene, hydroformylation products A complex combination of hydrocarbons produced by the distillation of products from the hydroformylation of octene. It consists predominantly of C8 olefins and paraffins, C9 alcohols and aldehydes, and C27 acetals and boils in the range of approximately 110 . DEGREES. C to 400 . DEGREES.C (230 . DEGREES. F to 752 . DEGREES. F). 68527059 0
Dodecene, hydroformylation products The complex combination of hydrocarbons produced by the hydroformylation of dodecene. It consists predominantly of C12 olefins and paraffins, C13 alcohols and aldehydes, and C39 acetals and boils in the range of approximately 160 . DEGREES. C to 450 . DEGREES. C (320 . DEGREES. F to 842 . DEGREES. F). 68527060 0
(1a,2b,5a) - 2,6,6 - trimethylbicyclo(3.1.1)heptane 6876137 0
Fatty acids, C12 - 18, Me esters This substance is identified by SDA Substance Name: C12 - C18 alkyl carboxylic acid methyl ester and SDA Reporting Number: 16 - 010 - 00. 68937848 0
Hydrocarbons, terpene processing by - products 68956569 0
White mineral oil (petroleum) A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominatly in the range of C15 through C50. 8042475 0
Resin acids and Rosin acids, hydrogenated, Me esters 8050155 0
Resin acids and Rosin acids, esters with glycerol 8050315 0
isobutyl isobutyrate 97858 0
4 - methylanisole 104938 1
methyl oleate 112629 1
tetradecanol 112721 1
2 - methylbutyric acid 116530 1
2,6,8 - trimethylnonan - 4 - one 123182 1
isopropyl palmitate 142916 1
dodecanenitrile 2437254 1
2 - ethylhexyl palmitate 29806733 1
4 - tert - butylcyclohexyl acetate 32210234 1
1,2,3,4 - tetrahydronaphthalen - 1 - ol 529339 1
Nitriles, coco 61789535 1
methyl 3 - (3,5 - di - tert - butyl - 4 - hydroxyphenyl)propionate 6386385 1
tributyl O - acetylcitrate 77907 1
camphene 79925 1
Linseed oil. Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acids linoleic, linolenic and oleic. (Linum usitatissimum, Linaceae). 8001261 1
p - menth - 1 - en - 8 - yl acetate 80262 1
4 - tert - butylcyclohexanol 98522 1
a - hexylcinnamaldehyde 101860 2
dibutyl maleate 105760 2
citronellol 106229 2
nerol 106252 2
isobutyl acetate 110190 2
methyl octanoate 111115 2
nonane 111842 2
linalyl acetate 115957 2
octanal 124130 2
pin - 2(10) - ene * 127913 2
2 - methylbutan - 1 - ol 137326 2
4 - allylanisole 140670 2
2,3,6 - trimethylphenol 2416946 2
myristic acid, pure 544638 2
3 - methylbut - 2 - en - 1 - ol 556821 2
butyl propionate 590012 2
3 - ethylphenol 620177 2
tridecane 629505 2
diisopropyl adipate 6938949 2
dimethyl sulphide 75183 2
Castor oil. Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acid ricinoleic. (Ricinus communis, Euphorbiaceae). and C16 - C22 unsatd. fatty acids. (Physeter). 8001794 2
Fusel oil A combination of amyl alcohols, primarily isoamyl alcohol and 2 - methyl - 1 - butanol. Other alcohols, acids, esters and aldehydes may also be present. 8013750 2
methyl p - toluate 99752 2
triacetin 102761 3
methyl acetoacetate 105453 3
butane - 1,3 - diol 107880 3
2,6 - dimethylheptan - 4 - ol 108827 3
propyl acetate 109604 3
1,1' - oxydipropan - 2 - ol 110985 3
benzyl salicylate 118581 3
4 - ethylphenol 123079 3
anisaldehyde 123115 3
octan - 2 - ol 123966 3
nonanal 124196 3
lauric acid, pure 143077 3
isodecyl alcohol 25339177 3
4 - (4 - hydroxy - 4 - methylpentyl)cyclohex - 3 - enecarbaldehyde 31906044 3
decanoic acid 334485 3
hexadecan - 1 - ol 36653824 3
(E) - anethole 4180238 3
glycerol trioctanoate 538238 3
citral * 5392405 3
2 - methyl - 6 - methyleneoct - 7 - en - 2 - ol 543395 3
tetradecane 629594 3
pentadecane 629629 3
pentan - 1 - ol 71410 3
isobutyric acid 79312 3
Soybean oil. Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acids linoleic, oleic, palmitic and stearic. (Soja hispida, Leguminosae). 8001227 3
Turpentine, oil * Any of the volatile predominately terpenic fractions or distillates resulting from the solvent extraction of, gum collection from, or pulping of softwoods. Composed primarily of the C10H16 terpene hydrocarbons: a - pinene, b - pinene, limonene, 3 - carene, camphene. May contain other acyclic, monocyclic, or bicyclic terpenes, oxygenated terpenes, and anethole. Exact composition varies with refining methods and the age, location, and species of the softwood source. 8006642 3
geraniol 106241 4
octan - 3 - one 106683  
butyric acid 107926 4
4 - methylpentan - 2 - ol 108112 4
2,6 - dimethylheptan - 4 - one 108838 4
isopropyl myristate 110270 4
heptan - 2 - one 110430 4
valeraldehyde 110623 4
hexan - 1 - ol 111273 4
heptanal 111717 4
undecan - 1 - ol 112425 4
dodecan - 1 - ol 112538 4
methyl salicylate 119368 4
benzophenone 119619 4
2 - ethylhexanal 123057 4
7 - methyl - 3 - methyleneocta - 1,6 - diene 123353 4
butyraldehyde 123728 4
octanoic acid 124072 4
decane 124185 4
1,2 - benzisothiazol - 3(2H) - one 1,1 - dioxide, sodium salt 128449 4
methyl anthranilate 134203 4
benzyl acetate 140114 4
ethyl acetoacetate 141979 4
oxydipropanol 25265718 4
diethylbenzene 25340174 4
2,3 - xylenol 526750 4
3 - methylbutanone 563804 4
propane - 1,2 - diol 57556 4
2 - phenylpropan - 2 - ol 617947 4
isobutyraldehyde 78842 4
methyl acetate 79209 4
2 - (4 - tert - butylbenzyl)propionaldehyde 80546 4
pin - 2(3) - ene 80568 4
methyl benzoate 93583 4
2,5 - xylenol 95874 4
pentan - 3 - one 96220 4
p - menth - 1 - en - 8 - ol 98555 4
acetophenone 98862 4
benzaldehyde 100527 5
diphenyl ether 101848 5
2 - methylpentane - 2,4 - diol 107415 5
2,2' - oxydiethanol 111466 5
2 - (2 - methoxyethoxy)ethanol 111773 5
octan - 1 - ol 111875 5
2,2' - (ethylenedioxy)diethanol 112276 5
decan - 1 - ol 112301 5
dodecane 112403 5
propionaldehyde 123386 5
methyl myristate 124107 5
ethyl acetate 141786 5
(Z) - octadec - 9 - enol 143282 5
2 - tert - butyl - p - cresol 2409554 5
sodium benzoate 532321 5
hexadecane 544763 5
palmitic acid, pure 57103 5
stearic acid, pure 57114 5
2,6 - xylenol 576261 5
(R) - p - mentha - 1,8 - diene 5989275 5
2 - phenylethanol 60128 5
hexan - 2 - ol 626937 5
acetic acid, of a concentration of more than 10 per cent, by weight, of acetic acid 64197 5
butan - 1 - ol 71363 5
butan - 2 - ol 78922 5
1,2 - benzisothiazol - 3(2H) - one 1,1 - dioxide 81072 5
diethyl phthalate 84662 5
butyl methacrylate 97881 5
p - cymene 99876 5
ethylbenzene 100414 6
styrene 100425 6
benzyl alcohol 100516 6
2,2',2'' - nitrilotriethanol 102716 6
2 - ethylhexan - 1 - ol 104767 6
p - cresol 106445 6
1 - methoxypropan - 2 - ol 107982 6
4 - methylpentan - 2 - one 108101 6
m - cresol 108394 6
resorcinol 108463 6
phenol, pure 108952 6
valeric acid 109524 6
heptanoic acid 111148 6
2 - (2 - ethoxyethoxy)ethanol 111900 6
nonanoic acid 112050 6
2 - (2 - butoxyethoxy)ethanol 112345 6
oleic acid, pure 112801 6
vanillin 121335 6
2,6 - di - tert - butyl - p - cresol 128370 6
dimethyl phthalate 131113 6
cresol, pure 1319773 6
xylene, mixed isomers, pure 1330207 6
glycerol 56815 6
ethanol 64175 6
benzoic acid 65850 6
propan - 2 - ol 67630 6
2 - methylpropan - 2 - ol 75650 6
trometamol 77861 6
citric acid 77929 6
3,5,5 - trimethylcyclohex - 2 - enone 78591 6
isoprene 78795 6
2 - methylpropan - 1 - ol 78831 6
butanone 78933 6
dibutyl phtalate 84742 6
coumarin 91645 6
o - cresol 95487 6
dimethyl malonate 108598 *
heptan - 1 - ol 111706 *
methyl palmitate 112390 *
benzyl benzoate 120514 *
2 - benzylideneheptanal 122407 *
4 - methylpent - 3 - en - 2 - one 141797 *
2,6,6 - trimethylbicyclo(3.1.1)heptane - 3 - ol 473541 *
2,6,6 - trimethylbicyclo(3.1.1)heptane 473552 *
isovaleric acid 503742 *
guaiacol 90051 *
2 - methylnaphthalene 91576 *
2 - methylbutyraldehyde 96173 *
ethyl lactate 97643 *
tetrahydrofurfuryl alcohol 97994 *
furfuryl alcohol 98000 *
4 - tert - butyltoluene 98511 *
1 - phenylethanol 98851 *
Ionone, methyl - 1335462 *
2 - tert - butylhydroquinone 1948330 *
3,7 - dimethylocta - 1,6 - diene 2436900 *
3a,4,5,6,7,7a - hexahydro - 4,7 - methanoinden - 6 - yl acetate 5413605 *
( - ) - pin - 2(3) - ene 7785264 *
Olive oil. Extractives and their physically modified derivatives. It consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. (Olea europaea, Oleaceae). 8001250 *

Hit Counter

 

The information contained on this site has been compiled by

Betty Bridges,RN

mailto:bcb56@ix.netcom.com

E-Fax:: (801)340-3578

09/19/00